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Acta Pharmacologica Sinica 2006 June; 27 (6): 754-759; doi: 10.1111/j.1745-7254.2006.00337.x |
| Original Article | [ Full text ] |
| In vitro characteristics of poly(lactic-co-glycolic acid) microspheres incorporating gelatin particles loading basic fibroblast growth factor |
Shao-hong LI1,4, Shao-xi CAI1,3 , Bing LIU1, Kai-wang MA1, Zhen-ping WANG1, Xiao-kun LI2 1Key Laboratory for Biomechanical and Tissue Engineering, State Ministry of Education, College of Bioengineerin, Chongqing University, Chongqing 400030, China; 2Gene Medicine Engineering Research Center, Jinan University, Guangzhou 510632, China |
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Aim: To construct a sustained drug release system for basic fibroblast growth factor (bFGF). With this special system, bFGF can be used to repair an injured peripheral nerve, injured spinal cord, or as a carrier for other drugs that need to be released over a long time.
Methods: Microsphere composite was prepared by encapsulating bFGF into gelatin particles with poly(lactic-co-glycolic acid) (PLGA) as its outer-coating. The encapsulation was conducted by a phase separation method.
Results: The average diameter of the gelatin particle-PLGA microsphere composite was 5-18 µm, and bFGF-loading efficiency was up to 80.5%. The bFGF releasing experiment indicated that this new composite system could release bFGF continuously and protect bFGF from denaturation.
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Keywords: poly(lactic-co-glycolic acid); gelatin; basic fibroblast growth factor; microsphere; delayed-action preparations |
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