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Acta Pharmacologica Sinica 2006 June; 27 (6): 673-678; doi: 10.1111/j.1745-7254.2006.00332.x |
| Original Article | [ Full text ] |
| High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia1 |
Si-yuan PAN2,4, Rong YANG2, Yi-fan HAN3, Hang DONG2, Xu-dong FENG2, Na LI2, Wei GENG2, Kam-ming KO3 2Department of Pharmacology, Beijing University of Chinese Medicine, Beijing 100029, China; 3Department of Biochemistry, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China |
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Aim: To investigate the effects of bifendate on serum and hepatic lipids level in rabbits and mice.
Methods: Animals were administered bifendate [powdered pill suspended in 0.5% sodium carboxymethylcellulose (CMC)] at increasing doses (0.25-1 g/kg, ig). Blood lipid and apolipoprotein levels were measured using commercially available assay kits.
Results: The treatment of rabbits with a single dose of bifendate (0.3 g/kg) caused a time-dependent and biphasic change in serum triglyceride (TG) levels, with the value reaching a maximum (3-fold increase compared to the baseline value) between 24 and 36 h post-dosing. When mice were orally treated with bifendate (0.25-1 g/kg), serum TG levels increased by 39%-76% and 14%-39% at 24 and 48 h post-dosing, respectively. When given at daily doses of 0.25 and 1 g/kg for 4 d, bifendate increased serum TG levels (56%-79%), with concomitant elevations in apolipoprotein A-I and apolipoprotein B levels at 24 h after the last dosing. TG levels were also increased (11%-43%) in liver samples of mice receiving single or multiple doses of bifendate. However, bifendate treatment caused slight reductions in serum and hepatic total cholesterol levels (9%-13%). The hypertriglyceridemia induced by bifendate was ameliorated by fenofibrate but not inositol nicotinate treatment in mice.
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Keywords: bifendate; fenofibrate; inositol nicotinate; triglycerides; total cholesterol; acute hyper-triglyceridemia |
| 1 Project supported by a grant from the Natural Science Foundation of Beijing City (No 7022017). |
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