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Acta Pharmacologica Sinica 2006 April; 27 (4): 387-394; doi: 10.1111/j.1745-7254.2006.00315.x |
| Review | [ Full text ] |
| SRC-3/AIB1: transcriptional coactivator in oncogenesis1 |
Jun YAN2, Sophia Y TSAI2, Ming-jer TSAI2,3,4 2Department of Molecular and Cellular Biology and 3Prostate SPORE, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA |
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Steroid receptor coactivator-3 (SRC-3, also known as NCoA3, AIB1, p/CIP, RAC3, ACTR, and TRAM1), localized on a frequently amplified region, 20q12, has been associated with multiple cancers, including breast, gastric and prostate cancers. Although SRC-3 has been implicated as an oncogene, compelling evidence has only recently emerged implicating it as a causal factor in the genesis of human cancers. Here, we summarize recent evidence that indicates aberrant SRC-3 expression is important in hormone-sensitive and -insensitive human cancers. |
Keywords: SRC-3/AIB1; oncogene; mouse model; cancer; signal transduction |
| 1 Project supported by grants from the National Institutes of Health (U01DK62 424) and Prostate SPORE (CA58204) to Ming-jer TSAT. |
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