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Acta Pharmacologica Sinica 2006 January; 27 (1): 27-40; doi: 10.1111/j.1745-7254.2006.00238.x |
| Review | [ Full text ] |
| Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds1 |
Andrzej B HENDRICH2 Department of Biophysics, Wroclaw Medical University, ul. Chalubinskiego 10, 50-368 Wroclaw, Poland |
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Flavonoids are found ubiquitously in higher plants and constitute an important component of the majority of peoples' daily diets. The biological activities of flavonoids cover a very broad spectrum, from anticancer and antibacterial activities through to inhibition of bone resorption. In the present paper, the interactions between flavonoids and lipid bilayers as well as biological membranes and their components are reviewed, with special emphasis on the structure-activity relationships and mechanisms underlying the biological activity of flavonoids. |
Keywords: flavonoids; lipid bilayers; antioxidation; anticancer activity; multidrug resistance |
| 1 Project supported by grant from the Ministry of Science and Information Society Technologies of Poland (2 P05A 090 20). |
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