Cover: Unstimulated platelets have smooth plasma membrane and dense granules (upper left panel). They transform to a spiny spherical shape with pseudopodia and reduce dense granules after thrombin stimulation (lower left panel). Pretreatment of platelets with prostaglandin A1 (upper right panel) but not vehicle (lower right panel) inhibits thrombin-induced morphological changes. (page 549-554).

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REVIEWS

Mutation trend of hemagglutinin of influenza A virus: a review from a computational mutation viewpoint.  [Page513-526]
Wu G, Yan SM
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ORIGINAL ARTICLES

Cardiovascular Pharmacology

Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats.  [Page527-535]
Li L, Zhang LK, Pang YZ, Pan CS, Qi YF, Chen L, Wang X, Tang CS, Zhang J
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Paradoxical effects of ginkgolide B on cardiomyocyte contractile function in normal and high-glucose environments.  [Page536-542]
Kim J, Li Q, Fang CX, Ren J
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Increased RhoA translocation in aorta of diabetic rats.  [Page543-548]
Tang J, Kusaka I, Massey AR, Rollins S, Zhang JH
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Prostaglandin A1 inhibits increases in intracellular calcium concentration, TXA2 production and platelet activation.  [Page549-554]
Zhu Y, Gu ZL, Liang ZQ, Zhang HL, Qin ZH
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Induction of collateral artery growth and improvement of post-infarct heart function by hepatocyte growth factor gene transfer.  [Page555-560]
Wang W, Yang ZJ, Ma DC, Wang LS, Xu SL, Zhang YR, Cao KJ, Zhang FM, Ma WZ
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Lung,Gastrointestinal,and Renal Pharmacology

Antisense oligonucleotides-induced local blockade of T-bet expression leads to airway inflammation in rats.  [Page561-567]
Wang G, Liu CT, Wang ZL, Jiang LL, Yan CL, Luo FM
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Proteomic analysis of differential protein expression in early process of pancreatic regeneration in pancreatectomized rats.  [Page568-578]
Yang M, Liu W, Wang CY, Liu T, Zhou F, Tao J, Wang Y, Li MT
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Changes in angiopoietin expression in glomeruli involved in glomerulosclerosis in rats with daunorubicin-induced nephrosis. [Page579-587]
Lu YH, Deng AG, Li N, Song MN, Yang X, Liu JS
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Role of 11-beta-hydroxysteroid dehydrogenase type 1 in differentiation of 3T3-L1 cells and in rats with diet-induced obesity.  [Page588-596]
Liu Y, Sun WL, Sun Y, Hu G, Ding GX
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Synthesis and anti-diabetic activity of (RS)-2-ethoxy-3-{4-[2-(4-trifluoromethanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propi onic acid.  [Page597-602]
Cai ZF, Liu Q, Li PP, Guo ZR, Shen ZF
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Andrology

Sulfasalazine prevents apoptosis in spermatogenic cells after experimental testicular torsion/detorsion.  [Page603-608]
Zhao YG, Zheng XM, Zhou J, Liu XL, Hu XM, Chen DH, Zhang XJ, Men XW, Shi HB, Yu ZY
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Immunopharmacology

Effects of adenoviral gene transfer of mutated IκBα, a novel inhibitor of NF-κB, on human monocyte-derived dendritic cells.  [Page609-616]
Zhou LF, Zhang MS, Yin KS, Ji Y, Xie WP, Cui XF, Ji XH
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Engagement of PSGL-1 enhances β2-integrin-involved adhesion of neutrophils to recombinant ICAM-1.  [Page617-622]
Wang XG, Cheng YP, Ba XQ
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Pharmacokinetics

Biosynthesis of imipramine glucuronide and characterization of imipramine glucuronidation catalyzed by recombinant UGT1A4.  [Page623-628]
Qian RM, Zeng S
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Influence of age and sex on pharmacodynamics of propofol in neurosurgical patients: model development. [Page629-634]
Li YH, Wu FS, Xu JG
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Metabolism and effect of para-toluene-sulfonamide on rat liver microsomal cytochrome P450 from in vivo and in vitro studies.  [Page635-640]
Zhou JQ, Tang ZQ, Zhang JN, Tang JC
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