Cover: siRNA and shRNA delivery and processing. Delivery of preformed siRNAs is achieved by transient transfection techniques such as lipofection or electroporation. Inside the cytoplasm, a Dicer-containing complex promotes the dissociation of the double-stranded siRNA to 2 single strands and the formation of a catalytically competent RISC. In the case of shRNAs, a vector containing an shRNA expression cassette enters the nucleus via transfection or viral infection. Inside the nucleus, the transcribed shRNAs are exported into the cytoplasm. Dicer-mediated processing towards siRNAs is followed by association with the other RISC components. (page 273-281).

previous issue  Vol 27 Issue 3 (2006)   next issue

REVIEWS

Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects [Page259-272]
Irena MANOV, Helen MOTANIS, Idan FRUMIN, Theodore C IANCU2
[Extract][Full text]

Targeting leukemic fusion proteins with small interfering RNAs: recent advances and therapeutic potentials [Page273-281]
Maria THOMAS2, Johann GREIL3, Olaf HEIDENREICH2,4
[Extract][Full text]

ORIGINAL ARTICLES

Neuropharmacology

Pranlukast reduces neutrophil but not macrophage/microglial accumulation in brain after focal cerebral ischemia in mice [Page282-293]
Li-sheng CHU2,3, Er-qing WEI2,4, Guo-liang YU2, San-hua FANG2, Yu ZHOU2, Meng-ling WANG2, Wei-ping ZHANG2
[Extract][Full text]

Electrophysiological effect of fluoxetine on Xenopus oocytes heterologously expressing human serotonin transporter  [Page289-293]
Hong-wei WANG2, Ci-zhen LI2, Zhi-fang YANG2, Yan-qian ZHENG2, Ying ZHANG2, Yuan-mou LIU2,3
[Extract][Full text]

Cardiovascular Pharmacology

Hydrogen sulfide facilitates carotid sinus baroreflex in anesthetized rats  [Page294-298]
Lin XIAO, Yu-ming WU1, Hao ZHANG, Yi-xian LIU, Rui-rong HE
[Extract][Full text]

Hydrogen sulfide ameliorates vascular calcification induced by vitamin D3 plus nicotine in rats  [Page299-306]
Sheng-ying WU2,6, Chun-shui PAN3, Bin GENG3, Jing ZHAO3, Fang YU3, Yong-zheng PANG3, Chao-shu TANG4, Yong-fen QI3,4,5
[Extract][Full text]

Inhibitory effect of Ca2+ on in vivo gene transfer by electroporation  [Page307-310]
Yong-gang ZHAO2, Hui-li LU2, Jin-liang PENG2, Yu-hong XU2,3,4
[Extract][Full text]

Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro [Page311-320]
Dan-yan ZHU, Yi-jia LOU2
[Extract][Full text]

Baculovirus ETL promoter acts as a shuttle promoter between insect cells and mammalian cells [Page321-327]
Yu-kou LIU2,4, Chih-chieh CHU2,4, Tzong-yuan WU3,5
[Extract][Full text]

Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients  [Page328-332]
Yan FU1,2, Chang-he FAN2, He-huang DENG, San-hong HU, De-peng LV, Li-hua LI, Jun-jie WANG, Xin-qiao LU
[Extract][Full text]

Immunopharmacology

Enhancement of binding activity of soluble human CD40 to CD40 ligand through incorporation of an isoleucine zipper motif  [Page333-338]
Xian-hui HE2,3, Li-hui XU,4, Yi LIU2,5
[Extract][Full text]

Pulmonary Pharmacology

N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-kB activation in alveolar macrophages by different mechanisms  [Page339-346]
Ya-qing LI, Zhen-xiang ZHANG1, Yong-jian XU, Wang NI, Shi-xin CHEN, Zhao YANG , Dan MA
[Extract][Full text]

Antitumor Pharmacology

Knockdown of Stat3 expression using RNAi inhibits growth of laryngeal tumors in vivo  [Page347-352]
Li-fang GAO1, Lian-ji WEN2, Hao YU1, Ling ZHANG1, Yan MENG1, Yue-ting SHAO1, De-qi XU3,4, Xue-jian ZHAO1,4
[Extract][Full text]

Adenovirus-mediated expression of both antisense ODC and AdoMetDC inhibited colorectal cancer cell growth in vitro [Page353-359]
Bing ZHANG2, Xian-xi LIU2,5, Yan ZHANG2, Chun-ying JIANG3, Qing-shan TENG4, Hai-yan HU2, Wei WANG2, Lei GONG2
[Extract][Full text]

Curcumin inhibits WT1 gene expression in human leukemic K562 cells [Page360-366]
Songyot ANUCHAPREEDA2, Pattra THANARATTANAKORN3, Somjai SITTIPREECHACHARN3, Prasit CHANARAT2, Pornngarm LIMTRAKUL4,5
[Extrct][Full text]

Pharmacokinetics

Pharmacokinetics of CPU0213, a novel endothelin receptor antagonist, after intravenous administration in mice [Page367-371]
Li GUAN2, Yu FENG2, Min JI4, De-zai DAI2,3
[Extract][Full text]

Role of rat liver cytochrome P450 3A and 2D in metabolism of imrecoxib  [Page372-380]
Hai-yan XU2, Zhi-yong XIE2, Peng ZHANG2, Jin SUN3, Feng-ming CHU4, Zong-ru GUO4, Da-fang ZHONG2,5
[Extract][Full text]

Multiple dose pharmacokinetics of risperidone and 9-hydroxyrisperidone in Chinese female patients with schizophrenia  [Page381-386]
Zhi-ling ZHOU2, Xin LI3, Huai-yan PENG4, Xi-yong YU2, Ming YANG2, Feng-li SU1, Feng WANG1, Rong-hua ZHU1, Chun-yu DENG2, Qiu-xiong LIN2, Chuan-yue WANG5, Wen-biao LI5, Shu-guang LIN2, Huan-de LI1,6
[Extract][Full text]


Copyright©APS 2005
Add: 294 Tai-Yuan Road,Shanghai 200031,China
Phn: 86-21-5492-2821 Fax: 86-21-5492-2823
E-mail: aps@mail.shcnc.ac.cn