Cover:Roles of nAChRs in mediating Aβ toxicity. Soluble Aβ1-42accumulation: (1) activates α7-nAChR and induces Ca2+ influx though this receptor and increases Ca2+ release from intracellular Ca2+ pool (ER); (2) combines to intracellular α7-nAChR and favors intracellular plaque formation; (3) activates presynaptic α7-nAChR located on glutamatergic terminal and increases glutamate release, then induces Ca2+ influx via both NMDA receptor and voltage-gated Ca2+ channels; (4) inhibits a4b2-nAChR and causes receptor up-regulation, and these α4β2-nAChR can be activated by endogenous ACh which depolarize membrane potential and in turn leads to the Ca2+ influx via both NMDA receptor and voltage-gated Ca2+ channels. NR1: a7-nAChRs; NR2: non-α7-nAChRs; ER: endoplasmic reticulum (page 1277_1286).

  Vol 27 Issue 10 (2006)  

REVIEWS

Neuronal nicotinic acetylcholine receptors serve as sensitive targets that mediate β-amyloid neurotoxicity.[Page1277-1286]
Qiang LIU, Jie WU²
[Extract][Full text]

Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies.[Page1287-1302]
Lin-hui WANG², Zheng-hong QIN^3,4
[Extract][Full text]

Traditional Chinese medicine in treatment of opiate addiction.[Page1303-1308]
Jie SHI², Yan-li LIU³, Yu-xia FANG⁴, Guo-zhu XU², Hai-fen ZHAI², Lin LU^2,5,6
[Extract][Full text]

ORIGINAL ARTICLES

Neuropharmacology

Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus.[Page1309-1316]
Ying JIN^2,4, Ying FAN², En-zhi YAN², Zhuo LIU², Zhi-hong ZONG³, Zhi-min QI ²
[Extract][Full text]

Effects of resveratrol and methylprednisolone on biochemical, neurobehavioral and histopathological recovery after experimental spinal cord injury.[Page1317-1325]
Ozkan ATES^1,6, Suleyman CAYLI¹, Eyup ALTINOZ², Iclal GURSES³, Neslihan YUCEL⁴, Ayhan KOCAK¹, Saim YOLOGLU⁵, Yusuf TURKOZ²
[Extract][Full text]

Cardiovascular Pharmacology

Inhibitory effects of cariporide on LPC-induced expression of ICAM-1 and adhesion of monocytes to smooth muscle cells in vitro. [Page1326-1332]
Zhi LI, Tao SONG, Gui-zhen LIU, Li-ying LIU²
[Extract][Full text]

Deferiprone protects the isolated atria from cardiotoxicity induced by doxorubicin.[Page1333-1339]
Ling-jie XU^{1, 4} , Liang JIN¹, Hong PAN¹, Ao-zhen ZHANG², Gang WEI¹, Ping-ping LI³, Wei-yue LU^{1, 5}
[Extract][Full text]

Pulmonary Pharmacology

Calcitonin gene-related peptide inhibits interleukin-1β-induced interleukin-8 secretion in human type II alveolar epithelial cells.[Page1340-1345]
Wen-jing LI, Teng-ke WANG, Xian WANG²
[Extract][Full text]

Endocrine Pharmacology

Antidiabetic effect of a novel non-thiazolidinedione PPAR γ/α agonist on ob/ob mice.[Page1346-1352]
Xi HU, Ying FENG, Yu SHEN, Xiao-feng ZHAO, Juan-hong YU, Yu-she YANG, Ying LENG²
[Extract][Full text]

Reproductive Pharmacology

Translocation of classical PKC and cortical granule exocytosis of human oocyte in germinal vesicle and metaphase II stage.[Page1353-1358]
Xue-qing WU^2,3,4,5,6, Xiao ZHANG^2,3,5, Xiao-hong LI^3,6, Hui-hong CHENG³, Yan-rong KUAI³, Song WANG³, Ying-lu GUO²
[Extract][Full text]

Immunopharmacology

Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis.[Page1359-1366]
Ha-young LEE^2,3,4, Eun-ha SHIN^2,4, Yoe-sik BAE^2,3,5
[Extract][Full text]

Anti-tumor Pharmacology

Efflux of potassium ion is an important reason of HL-60 cells apoptosis induced by tachyplesin.[Page1367-1374]
Hai-tao ZHANG^2,4, Jun WU³, Hai-feng ZHANG², Qi-feng ZHU
[Extract][Full text]

Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel, flavopiridol, and 5-fluorouracil.[Page1375-1381]
Jun GUO², An-wu ZHOU², Yu-cai FU³, Udit N VERMA², Debu TRIPATHY², Eugene P FRENKEL^2,5, Carlos R BECERRA⁴
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Pharmaceutics

In vitro and in vivo evaluation of a novel oral insulin formulation.[Page1382-1388]
Er-li MA, Hong MA, Zheng LIU, Chang-xue ZHENG, Ming-xing DUAN²
[Extract][Full text]

Ma EL, Ma H, Liu Z, Zheng CX, Duan MX

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