Acta Pharmacologica Sinica 2006 February; 27 (2): 217-222; doi: 10.1111/j.1745-7254.2006.00225.x

 
Original Article
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Magnesium lithospermate B ameliorates renal cortical microperfusion in rats1
 

Chun-guang CHEN2,3, Yi-ping WANG2,4

2State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences; 3Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China

 

Aim: To investigate the effects of magnesium lithospermate B (MLB) isolated from Salviae miltiorrhizae on renal microcirculation, and renal and systemic hemodynamics in Sprague-Dawley rats.

 

Methods: MLB (10, 30, and 60 mg/kg) was injected intravenously and renal blood flow (RBF), renal cortical microperfusion (RCM), and systemic hemodynamic function parameters including heart rate (HR), mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), and maximal velocity of pressure increase (dp/dtmax) were measured for 45 min after administration.

 

Results: Intravenous MLB at doses of 10, 30, and 60 mg/kg increased RCM significantly, but had no obvious effects on RBF or systemic hemodynamics. The effect of MLB on RCM reached its peak 15 min after injection and returned to baseline after 45 min. Up to 60 mg/kg MLB increased RCM by 62.4%±20.2% (changes from baseline, P<0.01), whereas RBF (3.7%±9.7% vs baseline) and renal vascular resistance (-1.4%±9.1% vs baseline) did not obviously change.


Conclusion:
These results indicate that MLB ameliorates renal microcirculation in a dose-dependent manner, which may be related to the renoprotective effects of MLB.

 

Keywords: magnesium lithospermate B; hemodynamics; renal blood flow; renal cortical microperfusion

 
1 Project supported by the National High Technology Research and Development Program of China (863 Program, No 2003AA2Z3269).

4 Correspondence to Prof Yi-ping WANG.
Phn 86-21-5080-6733.
Fax 86-21-5080-7088.
E-mail ypwang@mail.shcnc.ac.cn
Received 2005-04-25     Accepted 2005-08-25

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