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Acta Pharmacologica Sinica 2006 December; 27 (12): 1594-1599; doi: 10.1111/j.1745-7254.2006.00446.x |
| Original Article | [ Full text ] |
| CCR3 monoclonal antibody inhibits airway eosinophilic inflammation and mucus overproduction in a mouse model of asthma |
Hua-hao SHEN2, Feng XU2, Gen-sheng ZHANG, Shao-bin WANG, Wei-hua XU Department of Respiratory Diseases, the Second Affiliated
Hospital, Zhejiang University College of Medicine,
Hangzhou 310009, China |
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Aim: To explore the effect of a rat anti-mouse CC-chemokine receptor-3 (CCR3)monoclonal antibody (CCR3 mAb) on airway eosinophilia and mucus overproduction in asthmatic mice.
Results: CCR3 mAb significantly suppressed the increased eosinophils in the BALF and lung tissues in OVA-challenged mice compared with ns-IgG-treated mice. IL-5 levels in the BALF in CCR3 mAb and ns-IgG administration mice exhibited no obvious changes relative to OVA-challenged asthmatic mice. CCR3 mAb reduced the increased GCP and AMI after OVA challenge and decreased the enhanced expression of MUC5AC and EGFR mRNA in lung tissues in asthmatic animals.
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Keywords: asthma; CCR3 monoclonal antibody; eosino-philic inflammation; mucus overproduction; MUC5AC; epidermal growth factor receptor |
| 1 Project supported in part by the National Natural Science Foundation of China (No 30570807), key programs of the Natural Science Foundation of Zhejiang Province, China (No Z303761) and key programs of Science and Technology Association of Zhejiang Province (No 2003C24002). |
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