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Acta Pharmacologica Sinica 2005 Jun; 26 (6): 685-690; doi: 10.1111/j.1745-7254.2005.00092.x |
| Original Article | [ Full text ] |
| Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors1 |
Hua HU2,3, Gao CHEN2, Jian-min ZHANG2, Wei-ping ZHANG3, Lei ZHANG3, Qiu-fu GE3, Hong-tian YAO4, Wei DING4, Zhong CHEN3, Er-qing WEI3,5 2Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009; 3Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031; 4Department of Pathology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China |
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Aim: To determine the distribution of cysteinyl leukotriene receptor 2 (CysLT2), one of the cysteinyl leukotriene receptors, in human brains with traumatic injury and tumors. Methods: Brain specimens were obtained from patients who underwent brain surgery. CysLT2 in brain tissues was examined using immunohistochemical analysis. Results: CysLT2 was expressed in the smooth muscle cells (not in the endothelial cells) of arteries and veins. CysLT2 was also expressed in the granulocytes in both vessels and in the brain parenchyma. In addition, CysLT2 was detected in neuron- and glial-appearing cells in either the late stages of traumatic injury or in the area surrounding the tumors. Microvessels regenerated 8 d after trauma and CysLT2 expression was recorded in their endothelial cells.
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Keywords: cysteinyl leukotriene receptor 2; brain injuries; brain neoplasms; vascular smooth muscle cell |
| 1 Project supported by the National Natural Science Foundation of China (No 30271498) and the National Basic Research Program of China (No G1999054000). |
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