Cover: A number of recombinant approaches are being exploited to the production of IgG-like bispecific antibodies. Compared to the smaller antibody fragments, the IgG-like bispecific antibodies contain the full-length Fc region which confers not only longer in vivo half-life, but also the capability of mediating immune effector mechanisms including antibody-dependent cellular cytotoxicity (see page 649-58).

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REVIEWS

Antibody engineering: facing new challenges in cancer therapy.  [Page 641-648]
Sanz L, Cuesta ÁM, Compte M, Álvarez-Vallina L
[Extract] [Full text]

Recombinant approaches to IgG-like bispecific antibodies.  [Page 649-658]
Marvin JS, Zhu ZP
[Extract] [Full text]

Cytogenetic and molecular genetic alterations in hepatocellular carcinoma.  [Page 659-665]
Lau SH, Guan XY
[Extract] [Full text]


ORIGINAL ARTICLES

Neuropharmacology

Gene expression profile of amyloid beta protein-injected mouse model for Alzheimer disease. [Page 666-672]
Kong LN, Zuo PP, Mu L, Liu YY, Yang N
[Extract] [Full text]

Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells. [Page 673-678]
Tang LL, Wang R, Tang XC
[Extract] [Full text]

Overexpression of dishevelled-1 attenuates wortmannin-induced hyperphosphorylation of cytoskeletal proteins in N2a cell. [Page 679-684]
Wang HH, Zhang AH, Zhu LQ, Wang Q, Wang JZ
[Extract] [Full text]

Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors. [Page 685-690]
Hu H, Chen G, Zhang JM, Zhang WP, Zhang L, Ge QF, Yao HT, Ding W, Chen Z, Wei EQ
[Extract] [Full text]

Cardiovascular Pharmacology
Fibrin(ogen)olytic character of FIIa isolated from Agkistrodon acutus venom. [Page 691-695]
Wang YW, Liang XX, Chen JS, Chen Q, Qiu PX, Lin X, Yan GM
[Extract] [Full text]

Effects of simvastatin on cardiac performance and expression of sarcoplasmic reticular calcium regulatory proteins in rat heart. [Page 696-704]
Zheng X, Hu SJ
[Extract] [Full text]

Cell and Molecular Pharmacology
Differential regulation of cadherin expression by osteotropic hormones and growth factors in vitro in human osteoprogenitor cells. [Page 705-713]
Liu P, Lin JH, Zhang B
[Extract] [Full text]

Pulmonary Pharmacology
Transforming growth factor-b1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population. [Page 714-720]
Su ZG, Wen FQ, Feng YL, Xiao M, Wu XL
[Extract] [Full text]

Endocrine Pharmacology
Protective effects of bendazac lysine on early experimental diabetic nephropathy in rats. [Page 721-728]
Yin XX, Zhang YD, Shen JP, Wu HW, Zhu X, Li LM, Qiu J, Jiang SJ, Zheng XG
[Extract] [Full text]

Hepatopharmacology
Inhibitory effect of picroside II on hepatocyte apoptosis. [Page 729-736]
Gao H, Zhou YW
[Extract] [Full text]

Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis. [Page 737-744]
Liu LL, Gong LK, Qi XM, Cai Y, Wang H, Wu XF, XiaoY, Ren J
[Extract] [Full text]

Melatonin-selenium nanoparticles protects liver against immunological injury induced by bacillus Calmette-Guérin and lipopolysaccharide. [Page 745-752]
Wang H, Wei W, Zhang SY, Shen YX, Wang NP, Yue L, Xu SY
[Extract] [Full text]

Antitumor Pharmacology
Peroxisome proliferator-activated receptor g ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines. [Page 753-761]
Yang FG, Zhang ZW, Xin DQ, Shi CJ, Wu JP, Guo YL, Guan YF
[Extract] [Full text]

Inhibition of tumor growth and metastasis with antisense oligonucleotides (Cantide) targeting hTERT in an in situ human hepatocellular carcinoma model. [Page 762-768]
Lin RX, Tuo CW, Lü QJ, Zhang W, Wang SQ
[Extract] [Full text]

 


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