Cover: Ginseng has been used as a tonic remedy in Chinese traditional medicine for over 2000 years. More than 40 ginsenosides have been isolated from ginseng. Among them, Rg1 and Rb1 are main active principle of ginseng. The anti-amnestic and anti-aging effects of both compounds were overviewed in the present review (See pages 143-49).

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REVIEW

Development of novel therapies for Huntington's disease: hope and challenge.[Page 129-142]
Qin ZH, Wang J, Gu ZL
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Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action.[Page 143-149]
Cheng Y, Shen LH, Zhang JT
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ORIGINAL ARTICLES

Neuropharmacology
Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum.[Page 150-154]
Cao Y, Gu ZL, Lin F, Han R, Qin ZH
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Orexin A promotes histamine, but not norepinephrine or serotonin, release in frontal cortex of mice. [Page 155-159]
Hong ZY, Huang ZL, Qu WM, Eguchi N
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Modulating effect of adenosine deaminase on function of adenosine A1 receptors. [Page 160-165]
Sun WC, Cao Y, Jin L, Wang LZ, Meng F, Zhu XZ
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Modulation of P-glycoprotein function by amlodipine derivatives in brain microvessel endothelial cells of rats. [Page 166-170]
Ji BS, He L, Liu GQ
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Estrogen stimulates release of secreted amyloid precursor protein from primary rat cortical neurons via protein kinase C pathway. [Page 171-176]
Zhang S, Huang Y, Zhu YC, Yao T
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Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats. [Page 177-180]
Xu SJ, Chen Z, Zhu LJ, Shen HQ, Luo JH
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Effects of adenosine agonist R-phenylisopropyl-adenosine on halothane anesthesia and antinociception in rats. [Page 181-185]
Ma HC, Wang YF, Feng CS, Zhao H, Dohi S
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Effects of intrathecal 6-hydroxydopamine, a1 and a2 adrenergic receptor antagonists on antinociception of propofol in mice. [Page 186-191]
Ge ZJ, Zeng YM, Tan YF
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Effects of complete Freund's adjuvant on immunohistochemical distribution of IL-1b and IL-1R I in neurons and glia cells of dorsal root ganglion. [Page 192-198]
Li M, Shi J, Tang JR, Chen D, Ai B, Chen J, Wang LN, Cao FY, Li LL, Lin CY, Guan XM
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Inhibition of ATP-induced calcium influx in HT4 cells by glucocorticoids: involvement of protein kinase A. [Page 199-204]
Han JZ, Lin W, Chen YZ
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Cardiovascular Pharmacology
Onychin inhibits proliferation of vascular smooth muscle cells by regulating cell cycle. [Page 205-211]
Yang M, Huang HL, Zhu BY, Tuo QH, Liao DF
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Endocrine Pharmacology
Effect of a single dose of mifepristone on expression of pinopodes in endometrial surface of mice. [Page 212-219]
Huang DM, Nardo LG, Huang GY, Lu FE, Liu YJ
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Swietenia mahagony extract shows agonistic activity to PPARg and gives ameliorative effects on diabetic db/db mice. [Page 220-222]
Li DD, Chen JH, Chen Q, Li GW, Chen J, Yue JM, Chen ML, Wang XP, Shen JH, Shen X, Jiang HL
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Immunopharmacology
Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells. [Page 223-227]
Liu J, Wu QL, Feng YH, Yang YF, Li XY, Zuo JP
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Antitumor Pharmacology
RNA interference by expression of short hairpin RNAs suppresses bcl-xL gene expression in nasopharyngeal carcinoma cells. [Page 228-234]
Liu F, He CW, Zhang YF, Zhou KY
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Synthesis and anti-tumor activity of alkenyl camptothecin esters. [Page 235-241]
Cao ZS, Mendoza J, Dejesus A, Giovanella B
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Pharmaceutics
Effect of MePEG molecular weight and particle size on in vitro release of tumor necrosis factor-a-loaded nanoparticles. [Page 242-249]
Fang C, Shi B, Pei YY
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Pharmacokinetics
Pharmacokinetics and tissue distribution of 5-fluorouracil encapsulated by galactosylceramide liposomes in mice.[Page 250-256]
Jin Y, Li J, Rong LF, Lü XW, Huang Y, Xu SY
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