Cover: Two ligands for a GPCR, LPC vs proton. Agonism in neutral pH and antagonism in acidic pH by LPC on G2A GPCR are shown. Agonism by proton and two other possibilities are suggested. Another agonist in neutral pH and positively or negatively regulation on other GPCRs by proton are illustrated. (page 1435-1441).

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REVIEWS

Molecular mechanisms regulating expression and function of transcription regulator "inhibitor of differentiation 3"  [Page1409-1420]
Robert Wai-sui LIM, Jin-mei WU
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Molecular mechanism and regulation of autophagy1  [Page1421-1434]
Ya-ping YANG, Zhong-qin LIANG, Zhen-lun GU, Zheng-hong QIN
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Two ligands for a GPCR, proton vs lysolipid1  [Page1435-1441]
Dong-soon IM
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ORIGINAL ARTICLES

Differential sensitivity of GABAergic and glycinergic inputs to orexin-A in preganglionic cardiac vagal neurons of newborn rats1  [Page1442-1447]
Ji-jiang WANG,Yong-hua CHEN, Ke-yong LI, Feng-yan SUN
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Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats1  [Page1448-1453]
Li-sha XU, Li-xia YANG, Wei-wei HU, Xiao YU, Li MA, Lu-ying LIU, Er-qing WEI, Zhong CHEN
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Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion  [Page1454-1459]
Xia-min HU, Mi-mei ZHOU, Xian-min HU, Fan-dian ZENG
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C16, a novel advanced glycation endproduct breaker, restores cardiovascular dysfunction in experimental diabetic rats1  [Page1460-1466]
Gang CHENG, Li-li WANG, Wen-sheng QU, Long LONG, Hao CUI, Hong-ying LIU, Ying-lin CAO, Song LI
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One-oligonucleotide method for constructing vectors for RNA inter-ference1  [Page1467-1473]
Carlos Fabian FLORES-JASSO, Ines VELAZQUEZ-QUESADA, Carlos LANDA-SOLIS, Andres A GUTIERREZ, Luis VACA
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Enzymological characterization of FIIa, a fibrinolytic enzyme from Agkistrodon acutus venom1  [Page1474-1478]
Xiu-xia LIANG, Ying-na ZHOU, Jia-shu CHEN, Peng-xin QIU, Hui-zhen CHEN, Huan-huan SUN, Yu-ping WU, Guang-mei YAN
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Preparation and development of equine hyperimmune globulin F(ab')2 against severe acute respiratory syndrome coronavirus1  [Page1479-1484]
Jia-hai LU, Zhong-min GUO, Wen-yu HAN , Guo-ling WANG, Ding-mei ZHANG, Yi-fei WANG, Sheng-yun SUN, Qin-he YANG, Huan-ying ZHENG, Bing L WONG, Nan-shan ZHONG
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Binding of PLCd1PH-GFP to PtdIns(4,5)P2 prevents inhibition of phospholipase C-mediated hydrolysis of PtdIns(4,5)P2 by neomycin1  [Page1485-1491]
Chuan WANG, Xiao-na DU, Qing-zhong JIA, Hai-lin ZHANG
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Inhibitory effect of acetamide-45 on airway inflammation and phosphodiesterase 4 in allergic rats1  [Page1492-1496]
Kai WANG, Hua-hao SHEN, Jun-chun CHEN, Zhong CHEN
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Effect of cholecystokinin octapeptide on diacylglycerol-PKC signaling pathway in rat pulmonary interstitial macrophages stimulated by lipopolysaccharide1  [Page1497-1504]
Shun-jiang XU, Wei-juan GAO, Bin CONG, Chun-ling MA, Shu-jin LI, Yi-ling LING, Zhen-yong GU, Yu-xia YAO
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Evaluation of 2 celecoxib derivatives: analgesic effect and selectivity to cyclooxygenase-2/11  [Page1505-1511]
Zhi-hong LU, Xiao-yun XIONG, Bang-le ZHANG, Guo-cheng LIN, Yu-xiang SHI, Zhen-guo LIU, Jing-ru MENG, Yu-mei ZHOU, Qi-bing MEI
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Body distribution and in situ evading of phagocytic uptake by macrophages of long-circulating poly (ethylene glycol) cyanoacrylate-co-n-hexadecyl cyanoacrylate nanoparticles1  [Page1512-1518]
Min HUANG, Wei WU, Jun QIAN, Dan-jing WAN, Xiu-li WEI, Jian-hua ZHU
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Identification of some benproperine metabolites in humans and investigation of their antitussive effect1  [Page1519-1526]
Yan LI, Da-fang ZHONG, Si-wei CHEN, Isamu MAEBA
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Stereoselectivity in metabolic 3-reduction of tibolone in healthy Chinese female volunteers  [Page1527-1530]
Ming ZUO, Ming-jie GAO, Zhen LIU, Lei CAI, Geng-li DUAN
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