Cover: The discovered novel quinoxaline derivatives as potent cyclophilin D inhibitors exhibit highly inhibitory activity against Ca(2+)-dependent rat mitochondrial swelling and Ca(2+) uptake/release. Shown in the picture are the compounds binding to the binding pocket of rat cyclophilin D (page 1201-1211).

  Vol 26 Issue 10 (2005)  

REVIEWS

Introduction to 3D reconstruction of macromolecules using single particle electron microscopy¹  [Page1153-1164]
Oscar LLORCA²
[Extract][Full text]

HIV entry inhibitors: a new generation of antiretroviral drugs  [Page1165-1173]
Elias KRAMBOVITIS^1,3, Filippos PORICHIS^1,2, Demetrios A SPANDIDOS²
[Extract][Full text]

COMMENT

Perfect high throughput screening assay: a crucial technique for drug discovery  [Page1174-1174]
Guan-hua DU¹
[Extract][Full text]

ORIGINAL ARTICLES

A robust homogeneous binding assay for α4β2 nicotinic acetylcholine receptor¹  [Page1175-1180]
Xin HUI², Jie GAO², Xin XIE², Naoki SUTO³, Tsuyoshi OGIKU³, Ming-Wei WANG^2,4
[Extract][Full text]

Identification of human dopamine D1-like receptor agonist using a cell-based functional assay¹  [Page1181-1186]
Nan JIANG², Ke-qing OU-YANG³, Shao-xi CAI³, Ying-he HU², Zhi-liang XU^2,4
[Extract][Full text]

Comparative study on pharmacological effects of DM-phencynonate hydrochloride and its opticalisomers¹  [Page1187-1192]
Li-yun WANG, Jian-quan ZHENG², Yun WANG, Bo-hua ZHONG, Jin-xiu RUAN, Ke-liang LIU
[Extract][Full text]

Gene transfer of heat-shock protein 20 protects against ischemia/reperfusion injury in rat hearts¹  [Page1193-1200]
Yan-hui ZHU, Tie-min MA, Xian WANG²
[Extract][Full text]

Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca²⁺ uptake/release  [Page1201-1211]
Hong-xia GUO^2,3, Feng WANG^2,3, Kun-qian YU³, Jing CHEN³, Dong-lu BAI³, Kai-xian CHEN³, Xu SHEN^3,4,5, Hua-liang JIANG^3,4,5
[Extract][Full text]

Effects of propyl gallate on interaction between TNF-a and sTNFR-I using an affinity biosensor¹  [Page1212-1616]
Jing LI, Jia-dong HUANG, Bao-yan WU, Qiang CHEN²
[Extract][Full text]

Assessing phylogenetic relationships of Lycium samples using RAPD and entropy theory¹  [Page1217-1224]
Xiao-lin YIN^2,3, Kai-tai FANG⁴, Yi-zeng LIANG⁵, Ricky NS WONG⁶, Amber WY HA⁶
[Extract][Full text]

Cloning, expression, and characterization of pollen allergens from Humulus scandens (Lour) Merr and Ambrosia artemisiifolia L¹  [Page1225-1232]
Ai-lin TAO^2,3, Shao-heng HE^2,4
[Extract][Full text]

Role of arachidonic acid in hyposmotic membrane stretch-induced increase in calcium-activated potassium currents in gastric myocytes¹  [Page1233-1242]
Meng YANG², Xing-lan LI³, Hui-ying XU³, Jia-bin SUN³, Bin MEI⁴, Hai-feng ZHENG³, Lian-hua PIAO³, De-gang XING³, Zhai-liu LI³, Wen-xie XU^2,5
[Extract][Full text]

Anti-implantation effect of droloxifene in rats and its relationship with anti-estrogenic activity¹  [Page1243-1247]
Yong HUANG, Yu SHEN, Ying FENG, Lin CAO, Ying LENG²
[Extract][Full text]

Anticancer activity of sodium caffeate and its mechanism¹  [Page1248-1252]
Feng XU^2,3,4, Sheng-hua ZHANG³, Rong-guang SHAO³, Yong-su ZHEN³
[Extract][Full text]

Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis¹  [Page1253-1258]
Bei HUANG^2,4, Gavin PORTER³
[Extract][Full text]

Radioimmunotherapy of carcinoma of colon with [¹³¹I]-labeled recombinant chimeric monoclonal antibodies to carcinoembryonic antigen  [Page1259-1264]
Qiu-jun LU¹, Guang-xing BIAN, Yuan-yuan CHEN, Min ZHANG, Shao-ming GUO, Li-qing WEN
[Extract][Full text]

Deguelin regulates nuclear pore complex proteins Nup98 and Nup88 in U937 cells in vitro¹  [Page1265-1273]
Hong-li LIU², Yan CHEN^2,3, Guo-hui CUI², Qiu-ling WU², Jing HE², Wei-hua CHEN², Jian-feng ZHOU⁴
[Extract][Full text]

Pharmacokinetics of sifuvirtide, a novel anti-HIV-1 peptide, in monkeys and its inhibitory concentration in vitro¹  [Page1274-1280]
Shu-jia DAI², Gui-fang DOU³, Xiao-hong QIAN^4,5, Hai-feng SONG⁴, Zhong-ming TANG², De-sheng LIU², Xiu-wen LIU², Liu-meng YANG⁶, Yong-tang ZHENG⁶, Qing LIANG⁷
[Extract][Full text]