Cover: The discovered novel quinoxaline derivatives as potent cyclophilin D inhibitors exhibit highly inhibitory activity against Ca(2+)-dependent rat mitochondrial swelling and Ca(2+) uptake/release. Shown in the picture are the compounds binding to the binding pocket of rat cyclophilin D (page 1201-1211).

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REVIEWS

Introduction to 3D reconstruction of macromolecules using single particle electron microscopy1  [Page1153-1164]
Oscar LLORCA2
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HIV entry inhibitors: a new generation of antiretroviral drugs  [Page1165-1173]
Elias KRAMBOVITIS1,3, Filippos PORICHIS1,2, Demetrios A SPANDIDOS2
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COMMENT

Perfect high throughput screening assay: a crucial technique for drug discovery  [Page1174-1174]
Guan-hua DU1
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ORIGINAL ARTICLES

A robust homogeneous binding assay for α4β2 nicotinic acetylcholine receptor1  [Page1175-1180]
Xin HUI2, Jie GAO2, Xin XIE2, Naoki SUTO3, Tsuyoshi OGIKU3, Ming-Wei WANG2,4
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Identification of human dopamine D1-like receptor agonist using a cell-based functional assay1  [Page1181-1186]
Nan JIANG2, Ke-qing OU-YANG3, Shao-xi CAI3, Ying-he HU2, Zhi-liang XU2,4
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Comparative study on pharmacological effects of DM-phencynonate hydrochloride and its opticalisomers1  [Page1187-1192]
Li-yun WANG, Jian-quan ZHENG2, Yun WANG, Bo-hua ZHONG, Jin-xiu RUAN, Ke-liang LIU
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Gene transfer of heat-shock protein 20 protects against ischemia/reperfusion injury in rat hearts1  [Page1193-1200]
Yan-hui ZHU, Tie-min MA, Xian WANG2
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Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca2+ uptake/release  [Page1201-1211]
Hong-xia GUO2,3, Feng WANG2,3, Kun-qian YU3, Jing CHEN3, Dong-lu BAI3, Kai-xian CHEN3, Xu SHEN3,4,5, Hua-liang JIANG3,4,5
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Effects of propyl gallate on interaction between TNF-a and sTNFR-I using an affinity biosensor1  [Page1212-1616]
Jing LI, Jia-dong HUANG, Bao-yan WU, Qiang CHEN2
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Assessing phylogenetic relationships of Lycium samples using RAPD and entropy theory1  [Page1217-1224]
Xiao-lin YIN2,3, Kai-tai FANG4, Yi-zeng LIANG5, Ricky NS WONG6, Amber WY HA6
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Cloning, expression, and characterization of pollen allergens from Humulus scandens (Lour) Merr and Ambrosia artemisiifolia L1  [Page1225-1232]
Ai-lin TAO2,3, Shao-heng HE2,4
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Role of arachidonic acid in hyposmotic membrane stretch-induced increase in calcium-activated potassium currents in gastric myocytes1  [Page1233-1242]
Meng YANG2, Xing-lan LI3, Hui-ying XU3, Jia-bin SUN3, Bin MEI4, Hai-feng ZHENG3, Lian-hua PIAO3, De-gang XING3, Zhai-liu LI3, Wen-xie XU2,5
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Anti-implantation effect of droloxifene in rats and its relationship with anti-estrogenic activity1  [Page1243-1247]
Yong HUANG, Yu SHEN, Ying FENG, Lin CAO, Ying LENG2
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Anticancer activity of sodium caffeate and its mechanism1  [Page1248-1252]
Feng XU2,3,4, Sheng-hua ZHANG3, Rong-guang SHAO3, Yong-su ZHEN3
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Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis1  [Page1253-1258]
Bei HUANG2,4, Gavin PORTER3
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Radioimmunotherapy of carcinoma of colon with [131I]-labeled recombinant chimeric monoclonal antibodies to carcinoembryonic antigen  [Page1259-1264]
Qiu-jun LU1, Guang-xing BIAN, Yuan-yuan CHEN, Min ZHANG, Shao-ming GUO, Li-qing WEN
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Deguelin regulates nuclear pore complex proteins Nup98 and Nup88 in U937 cells in vitro1  [Page1265-1273]
Hong-li LIU2, Yan CHEN2,3, Guo-hui CUI2, Qiu-ling WU2, Jing HE2, Wei-hua CHEN2, Jian-feng ZHOU4
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Pharmacokinetics of sifuvirtide, a novel anti-HIV-1 peptide, in monkeys and its inhibitory concentration in vitro1  [Page1274-1280]
Shu-jia DAI2, Gui-fang DOU3, Xiao-hong QIAN4,5, Hai-feng SONG4, Zhong-ming TANG2, De-sheng LIU2, Xiu-wen LIU2, Liu-meng YANG6, Yong-tang ZHENG6, Qing LIANG7
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