Cover: Bispecific antibodies are powerful tools for the retargeting of effector mechanisms to disease-associated sites. Engineering of single-chain Fv fragments into recombinant bispecific antibody formats, such as diabodies, tandem-scFv molecules and derivatives thereof, has opened the possibility to generate bispecific molecules with properties advantageous for cancer therapy (See pages 1-9).

  Vol 26 Issue 1 (2005)  

REVIEW

Recombinant bispecific antibodies for cancer therapy. [Page 1-9]
Kontermann RE
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ORIGINAL ARTICLES

Neuropharmacology
Tonic activation of presynaptic GABA_B receptors on rat pallidosubthalamic terminals. [Page 10-16]
Chen L, Yung WH
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Intracellular dopamine oxidation mediates rotenone-induced apoptosis in PC12 cells. [Page 17-26]
Liu HQ, Zhu XZ, Weng EQ
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Cloning, expression, and functional analysis of human dopa-mine D1 receptors. [Page 27-32]
Sun WC, Jin L, Cao Y, Wang LZ, Meng F, Zhu XZ
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Antiapoptotic effect both in vivo and in vitro of A20 gene when transfected into rat hippocampal neurons. [Page 33-38]
Miao HS, Yu LY, Hui GZ, Guo LH
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Validation of a simple automated movement detection system for formalin test in rats. [Page 39-45]
Xie YF, Wang J, Huo FQ, Jia H, Tang JS
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Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats. [Page 46-50]
Wang CH, Chou WY, Hung KS, Jawan B, Lu CN, Liu JK, Hung YP, Lee TH
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Construction of phospholamban antisense RNA recombinant adeno-associated virus vector and its effects in rat cardiomyo-cytes. [Page 51-55]
Li J, Hu SJ, Sun J, Zhu ZH, Zheng X, Wang GZ, Yao YM, Chen NY, Zhao XY
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Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress. [Page 56-62]
Chen XC, Zhou YC, Chen Y, Zhu YG, Fang F, Chen LM
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Neuropeptide Y expression in mouse hippocampus and its role in neuronal excitotoxicity. [Page 63-68]
Wu YF, Li SB
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Cardiovascular Pharmacology
Alteration of binding sites for [³H]P1075 and [³H]glibenclamide in reno-vascular hypertensive rat aorta. [Page 69-76]
He HM, Long CL, Zhang LZ, Fu AL, Wang H
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Ca²⁺ participates in a_1B-adrenoceptor-mediated cAMP response in HEK293 cells. [Page 77-84]
Song Y, Li YF, Dong ED, Han QD, Zhang YY
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Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood. [Page 85-91]
Zeng XK, Guan YF, Remick DG, Wang X
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Effect of pravastatin on impaired endothelium-dependent relaxation induced by lysophosphatidylcholine in rat aorta. [Page 92-98]
Deng HF, Xiong Y
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Cellular and Molecular Pharmacology
Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique. [Page 99-106]
Chen S, Chen LL, Luo HB, Sun T, Chen J, Ye F, Cai JH, Shen JK, Shen X, Jiang HL
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Using support vector classification for SAR of fentanyl derivatives. [Page 107-112]
Dong N, Lu WC, Chen NY, Zhu YC, Chen KX
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Gastrointestinal Pharmacology
Evaluation of drug-muscarinic receptor affinities using cell membrane chromatography and radioligand binding assay in guinea pig jejunum membrane. [Page 113-116]
Yuan BX, Hou J, He LC, Yang GD
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Immunopharmacology
Melatonin attenuates 1-methyl-4-phenylpyridinium-induced PC12 cell death. [Page 117-123]
Bao JF, Wu RG, Zhang XP, Song Y, Li CL
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Pharmacokinetics
Pharmacokinetics of His-tag recombinant human endostatin in Rhesus monkeys. [Page 124-128]
Song HF, Liu XW, Zhang HN, Zhu BZ, Yuan SJ, Liu SY, Tang ZM
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