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Acta Pharmacologica Sinica 2005 February; 26 (2): 177-180; doi: 10.1111/j.1745-7254.2005.00032.x |
| Original Article | [ Full text ] |
| Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats1 |
| Shu-jun XU, Zhong CHEN, Li-jun ZHU, Hai-qing SHEN, Jian-hong LUO2 Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou
310031, China |
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Aim: To examine the basic expression levels of N-methyl-D-aspartate (NMDA) receptor NR1 and NR2B subunits in six brain regions of Sprague-Dawley (SD) rats with different visual recognition memory.
Results: The NR1 and NR2B subunit protein levels in the hippocampus of the high visual recognition memory group were 35.9% (P<0.01) and 53.4% (P<0.05) higher respectively than those in the low group. In addition, the NR2B level in the striatum in the high visual recognition memory group was 25.0% (P<0.05) higher than that in the low one. However, no significant difference was found in the levels of the subunits between the two groups in other brain regions. Conclusion: The visual recognition memory in rats is related to the basic expression level of NMDA receptor NR1/NR2B subtype in the hippocampus and striatum. |
Keywords: N-methyl-D-aspartate receptors; NR1 subunit; NR2B subunit; Western blotting; visual recognition memory |
| 1 Project supported by Key National Basic Research Program of China (No G2002CB-713808), and Outstanding Cross-Century Faculty Grant of the Ministry of Education of China, the National Natural Science Foundation of China (No 30270436 and 30371638). |
| 2 Correspondence to Prof Jian-hong LUO. Phn 86-571-8721-7268. Fax 86-571-8721-7044. E-mail luojianhong@zju.edu.cn Received 2004-08-11 Accepted 2004-11-15 |
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